|
KMID : 0385920010120010001
|
|
Journal of the Korean Society of Emergency Medicine
2001 Volume.12 No. 1 p.1 ~ p.11
|
|
|
Duration - Dependent Neuroprotective Effect of Post - Ischemic Mild Hypothermia in the Gerbil Global Ischemic - Reperfusion Model
|
|
최승필/Kim YM
김세경/박규남/최승필/배중훈/Kim SK/Park KN/Choi SP/Bae JH
|
|
|
Abstract
|
|
|
BACKGROUND: The present study was performed in order to evaluate the duration-dependent neuroprotective effect of post-ischemic mild hypothermia against delayed neuronal damage following transient global ischemia and to estimate the optimal duration of brief post-ischemic mild hypothermia.
METHODS:
Post-ischemic mild hypothermia of different duration(1 hour, 3 hours, and 6 hours) was performed immediately after 10-minute global ischemia in gerbils, and the hippocampal CA1 cell loss after 3 days was evaluated. The duration-dependent neuroprotective effect of post-ischemic mild(33-34degrees C) hypothermia of each duration was compared to the normothermic control by using histopathological methods.
RESULTS:
1, 3 and 6 hours of mild hypothermia immediately following reperfusion resulted in progressively increased protection from ischemic damage, 10.0+/-8.2%, 33.7+/-21.9%, and 75.9+/-13.4%, respectively. The 3-hour and the 6-hour post-ischemic mild hypothermia groups revealed significant decreases in hippocampal CA1 area cell loss compared to the normothermic control group(9.0+/-7.7%, p<0.05), and the 6-hour group had a greater preservation than the 3-hour group(p<0.05).
CONCLUSION:
The results suggest that post-ischemic mild hypothermia protects against delayed neuronal damage in the hippocampal CA1 area following 10-minute transient global ischemia: 3-hour post-ischemic mild hypothermia provides a potential reduction of neuronal damage, but a 6-hour treatment is more effective in preventing neuronal damage than a 3-hour one.
|
|
|
KEYWORD
|
|
|
Brain ischemia, Post-ischemic mild hypothermia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|